4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid → 6-Amino-5-benzyloxy-nicotinic acid

HRID 425887

반응식

HRID 425887 반응식
[CH2:1]([O:8][C:9]1[C:10]([NH2:16])=[N:11][CH:12]=[C:13](Br)[CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.CC1(C)C(C)(C)OB(C2C=CC([C:29]([OH:31])=[O:30])=CC=2)O1>>[NH2:16][C:10]1[C:9]([O:8][CH2:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)=[CH:14][C:13]([C:29]([OH:31])=[O:30])=[CH:12][N:11]=1

참가 물질

3

반응물 2

HCID 27346214-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acidHCID 206265543-(Benzyloxy)-5-bromopyridin-2-amine

생성물 1

HCID 211115026-Amino-5-benzyloxy-nicotinic acid

실험 절차

6-Amino-5-benzyloxy-nicotinic acid was prepared according to procedure 3 from 3-benzyloxy-5-bromo-pyridin-2-ylamine and 4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzoic acid. MS m/z 321 (M+1).

출처 및 근거

ORD 기록
ord-c37251ef88cf495e8126020f4b85ecb4
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08106197B2

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