홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Potassium Carbonate → 3-[3-[3-Fluoro-5-(4-methoxy-benzylamino)-benzyl]-5-isopropyl-2,6-dioxo-1,2,3,6-tetrahydro-pyrimidine-4-carbonyl]-5-methyl-benzonitrile

HRID 426233
노트
인쇄 미리보기

반응식

HRID 426233 반응식
Br[CH2:2][C:3]1[CH:4]=[C:5]([NH:10][CH2:11][C:12]2[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][CH:13]=2)[CH:6]=[C:7]([F:9])[CH:8]=1.[CH:20]([C:23]1[C:24](=[O:41])[NH:25][C:26](=[O:40])[NH:27][C:28]=1[C:29](=[O:39])[C:30]1[CH:35]=[C:34]([CH3:36])[CH:33]=[C:32]([C:37]#[N:38])[CH:31]=1)([CH3:22])[CH3:21].C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[F:9][C:7]1[CH:8]=[C:3]([CH:4]=[C:5]([NH:10][CH2:11][C:12]2[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][CH:13]=2)[CH:6]=1)[CH2:2][N:27]1[C:28]([C:29]([C:30]2[CH:31]=[C:32]([CH:33]=[C:34]([CH3:36])[CH:35]=2)[C:37]#[N:38])=[O:39])=[C:23]([CH:20]([CH3:22])[CH3:21])[C:24](=[O:41])[NH:25][C:26]1=[O:40]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 468803773-(5-Isopropyl-2,6-dioxo-1,2,3,6-tetrahydro-pyrimidine-4-carbonyl)-5-methyl-benzonitrileHCID 59184728(3-Bromomethyl-5-fluoro-phenyl)-(4-methoxy-benzyl)-amine

생성물 1

HCID 591847713-[3-[3-Fluoro-5-(4-methoxy-benzylamino)-benzyl]-5-isopropyl-2,6-dioxo-1,2,3,6-tetrahydro-pyrimidine-4-carbonyl]-5-methyl-benzonitrile수율 55.9%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To a mixture of (3-bromomethyl-5-fluoro-phenyl)-(4-methoxy-benzyl)-amine (570 mg, 1.758 mmol), 5-isopropyl-6-(3′-cyano-5′-methylbenzoyl)-2,4-pyrimidinedione (522 mg, 1.758 mmol), and anhydrous powdered potassium carbonate (243 mg, 1.758 mmol), was added DMF (10 ml). The mixture was then stirred for overnight at room temperature and evaporated in vacuo. The residue was dissolved in methanol-dichloromethane (1:9), filtered through celite pad, and evaporated in vacuo to give a light yellow syrup. The crude product was purified by silica gel column chromatography (eluent, EA:hexane (1:4)) to afford 531 mg of 3-{3-[3-fluoro-5-(4-methoxy-benzylamino)-benzyl]-5-isopropyl-2,6-dioxo-1,2,3,6-tetrahydro-pyrimidine-4-carbonyl}-5-methyl-benzonitrile (151) as a yellow solid.

후처리

  1. customevaporated in vacuo
  2. dissolutionThe residue was dissolved in methanol-dichloromethane (1:9)
  3. filtrationfiltered through celite pad
  4. customevaporated in vacuo
  5. customto give a light yellow syrup
  6. customThe crude product was purified by silica gel column chromatography (eluent, EA:hexane (1:4))

출처 및 근거

ORD 기록
ord-0ea59ea858cf4a24be80a45dc8e01918
출처 데이터셋
uspto-grants-2012_01
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08106064B2

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트