Ammonium Hydroxide → N-(4-(hydroxymethyl)pyridin-2-yl)acetamide
반응식
[C:1]([NH:4][C:5]1[CH:10]=[C:9]([CH2:11][O:12]C(=O)C)[CH:8]=[CH:7][N:6]=1)(=[O:3])[CH3:2].[OH-].[NH4+]>CO>[OH:12][CH2:11][C:9]1[CH:8]=[CH:7][N:6]=[C:5]([NH:4][C:1](=[O:3])[CH3:2])[CH:10]=1참가 물질
4
실험 절차
Acetic acid 2-acetylamino-pyridin-4-ylmethyl ester (4.2 g, 20 mmol) was stirred with ammonium hydroxide (10 ml) in methanol (50 ml) at room temperature. After 24 hr., the mixture was evaporated in vacuo and the residue was purified by silica gel column chromatography (eluent, EA) to afford 3.36 g (quantitative) of N-(4-hydroxymethyl-pyridin-2-yl)-acetamide as a pale yellow solid. m.p. 145° C.; 1H NMR (200 MHz, CDCl3/CD3OD) δ 2.19 (3H, s), 4.67 (2H, s), 7.08 (1H, d, J=5.0 Hz), 8.10 (1H, s), 8.17 (1H, d, J=5.0 Hz).
후처리
- custom, the mixture was evaporated in vacuo
- customthe residue was purified by silica gel column chromatography (eluent, EA)
출처 및 근거
- ORD 기록
- ord-74b0f4f33b4f4d9f8eaad8c8ea8668fd
- 출처 데이터셋
- uspto-grants-2012_01
- 특허 번호
- US08106064B2
반응 노트
불러오는 중…