Water → Methyl 2-(4-chloromethylphenoxy)propionate

HRID 426434노트

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HRID 426434 반응식
O[CH2:2][C:3]1[CH:15]=[CH:14][C:6]([O:7][CH:8]([CH3:13])[C:9]([O:11][CH3:12])=[O:10])=[CH:5][CH:4]=1.S(Cl)([Cl:18])=O.O>CN(C)P(=O)(N(C)C)N(C)C>[Cl:18][CH2:2][C:3]1[CH:15]=[CH:14][C:6]([O:7][CH:8]([CH3:13])[C:9]([O:11][CH3:12])=[O:10])=[CH:5][CH:4]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 24386Thionyl ChlorideHCID 18759642Methyl 2-(4-hydroxymethylphenoxy)propionate

생성물 1

HCID 18981037Methyl 2-(4-chloromethylphenoxy)propionate

시약·촉매·용매 1

HCID 12679Hexamethylphosphoramide용매

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온도
-10 °C

실험 절차

12 gm (0.058 mol) of methyl 2-(4-hydroxymethyl-phenoxy)-propionate were dissolved in 60 ml of hexamethylphosphoric acid triamide, the solution was cooled to -10° C., and 4.4 ml (0.06 mol) of thionyl chloride were added dropwise thereto. The resulting mixture was stirred for 30 minutes at 0° C. and then for one hour at 10° C., and subsequently poured into water. The aqueous mixture was extracted with ether, and the extract solution was washed with water, sodium bicarbonate solution and again with water, and dried. The ether was subsequently removed in vacuo at room temperature, leaving methyl 2-(4-chloromethyl-phenoxy)-propionate as a residue.

후처리

  1. waitfor one hour at 10° C.
  2. extractionThe aqueous mixture was extracted with ether
  3. washthe extract solution was washed with water, sodium bicarbonate solution and again with water
  4. customdried
  5. customThe ether was subsequently removed in vacuo at room temperature

출처 및 근거

ORD 기록
ord-e85283782f1743b38c530220aabbb815
출처 데이터셋
uspto-grants-1979_10
특허 번호
US04169720

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