Methanol → N-cyclohexyl-3,3-dimethoxy-butyramide

HRID 426543

반응식

HRID 426543 반응식
[CH:1]1([NH:7][C:8](=[O:13])[CH2:9][C:10](=[O:12])[CH3:11])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH:14]([O-])([O-])[O:15]C.[CH3:19]O>C1(C)C=CC(S(O)(=O)=O)=CC=1.N1C2C(=CC=CC=2)C=CC=1>[CH:1]1([NH:7][C:8](=[O:13])[CH2:9][C:10]([O:15][CH3:14])([O:12][CH3:19])[CH3:11])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

6

반응물 3

HCID 887MethanolHCID 70805N-CyclohexylacetoacetamideHCID 53629101Methylorthoformate

생성물 1

HCID 20390362N-cyclohexyl-3,3-dimethoxy-butyramide

시약·촉매·용매 2

HCID 6101p-Toluenesulfonic acid촉매HCID 7047Quinoline촉매

반응 조건

온도
25 °C

실험 절차

A mixture of 36.6 g of N-cyclohexyl-acetylacetamide, 32 g of methyl orthoformate, 100 ml of methanol and 1 g of p-toluene sulfonic acid was stirred for 4 hours at 25° C. and after the addition of 2 g of quinoline, the mixture was evaporated to dryness under reduced pressure. The residue was added to isopropyl ether and the mixture was cooled and vacuum filtered. The recovered precipitate was dried to obtain 40 g of N-cyclohexyl-3,3-dimethoxy-butyramide melting at 66° C.

후처리

  1. customthe mixture was evaporated to dryness under reduced pressure
  2. additionThe residue was added to isopropyl ether
  3. temperaturethe mixture was cooled
  4. filtrationvacuum filtered
  5. customThe recovered precipitate was dried

출처 및 근거

ORD 기록
ord-0129d5d8f9f04f7ba04bc9fb4c31988a
출처 데이터셋
uspto-grants-1979_10
특허 번호
US04170465

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