p-Bromochlorobenzene → (p-Chlorophenyl)(diethyl)phosphine
반응식
[CH2:1]([P:3](Cl)[CH2:4][CH3:5])[CH3:2].[Cl:7][C:8]1[CH:13]=[CH:12][C:11]([Li])=[CH:10][CH:9]=1.ClC1C=CC(Br)=CC=1>CCOCC>[Cl:7][C:8]1[CH:13]=[CH:12][C:11]([P:3]([CH2:4][CH3:5])[CH2:1][CH3:2])=[CH:10][CH:9]=1참가 물질
5
실험 절차
A solution of 10 g. (0.08 mole) of diethylphosphinous chloride in 100 ml. of ether was added to a solution of p-chlorophenyllithium [prepared from 15.4 g. (0.08 mole) of p-chlorobromobenzene in 100 ml. of ether and 54 ml. of 1.5M n-butyllithium in hexane] under a nitrogen atmosphere. After 30 minutes, the reaction mixture was quenched with a few drops of ethyl acetate and the solvent was removed at reduced pressure. Distillation of the residual oil gave (p-chlorophenyl) (diethyl)phosphine, b.p. 86°-89° C. at 1.5 mm.
후처리
- customthe reaction mixture was quenched with a few drops of ethyl acetate
- customthe solvent was removed at reduced pressure
- distillationDistillation of the residual oil
출처 및 근거
- ORD 기록
- ord-58928434ae5c48f7a799bc0a8e1d4493
- 출처 데이터셋
- uspto-grants-1979_10
- 특허 번호
- US04171360
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