2-(1-Piperazinyl)-4-amino-6,7-dimethoxyquinazoline → HCID 21183901, 화합물

반응식

[S:1]1[C:5]([C:6]([Cl:8])=[O:7])=[CH:4][N:3]=[N:2]1.[NH2:9][C:10]1[C:19]2[C:14](=[CH:15][C:16]([O:22][CH3:23])=[C:17]([O:20][CH3:21])[CH:18]=2)[N:13]=[C:12]([N:24]2[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]2)[N:11]=1>>[ClH:8].[NH2:9][C:10]1[C:19]2[C:14](=[CH:15][C:16]([O:22][CH3:23])=[C:17]([O:20][CH3:21])[CH:18]=2)[N:13]=[C:12]([N:24]2[CH2:29][CH2:28][N:27]([C:6]([C:5]3[S:1][N:2]=[N:3][CH:4]=3)=[O:7])[CH2:26][CH2:25]2)[N:11]=1

참가 물질

반응물 2

HCID 6162672-(1-Piperazinyl)-4-amino-6,7-dimethoxyquinazoline

HCID 227144101,2,3-Thiadiazole-5-carbonyl chloride

생성물 1

HCID 21183901HCID 21183901, 화합물

실험 절차

Reaction of 1,2,3-thiadiazole-5-carbonyl chloride and 4-amino-6,7-dimethoxy-2-(1-piperzinyl)quinazoline according to the procedure of Example 1 provided the title compound having a melting point of 295°-297° C. after crystallization from aqueous ethanol.

출처 및 근거

ORD 기록: ord-92aed7c81538473d9853220bb57ab8a7
출처 데이터셋: uspto-grants-1979_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04171363

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