Water → 5,8-Difluoro-1,4-benzodioxane

HRID 426746

반응식

HRID 426746 반응식
F[C:2]1[C:11]([F:12])=[CH:10][CH:9]=[C:8]([F:13])[C:3]=1[O:4][CH2:5][CH2:6][OH:7].C(=O)([O-])[O-].[K+].[K+].O>CN(C)C=O>[F:12][C:11]1[C:2]2[O:7][CH2:6][CH2:5][O:4][C:3]=2[C:8]([F:13])=[CH:9][CH:10]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 11430Potassium CarbonateHCID 27779442-(2,3,6-Trifluorophenoxy)ethanol

생성물 1

HCID 44642425,8-Difluoro-1,4-benzodioxane

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

2-(2,3,6-Trifluorophenoxy) ethanol (48.8 g, 0.254 mole) and 24 g of anhydrous potassium carbonate in 800 ml of dimethylformamide was refluxed for 20 hours and then poured into water. This was extracted with ether, washed with water, and dried to give 5,8-difluoro-1,4-benzodioxane.

후처리

  1. extractionThis was extracted with ether
  2. washwashed with water
  3. customdried

출처 및 근거

ORD 기록
ord-f8ca3c9a2c7248d7b8e319529edd37db
출처 데이터셋
uspto-grants-1979_10
특허 번호
US04171359

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