4-Fluorobenzylamine → 2-Pyrrolidinone, 1-((4-fluorophenyl)methyl)-
반응식
[F:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][NH2:7])=[CH:4][CH:3]=1.[O:10]1[CH:14]=[CH:13][CH2:12][C:11]1=O>C1(C=CC(O)=CC=1)O>[F:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][N:7]2[CH2:14][CH2:13][CH2:12][C:11]2=[O:10])=[CH:4][CH:3]=1참가 물질
4
실험 절차
47 g (0.376 mol) of p-fluorobenzylamine, 30.4 g (0.353 mol) of furan-2-one and 0.4 g of hydroquinone are introduced into a 125 ml autoclave. After driving the air out of the apparatus by passing a stream of nitrogen through it, the mixture is heated to 250° for 6 hours. It is then cooled and distilled under reduced pressure. 51 g (yield=74.8%) of 1-p-fluorobenzyl-pyrrolidin-2-one are collected as a colourless liquid distilling at 103°-105° under a pressure of 0.01 mm of mercury and solidifying slowly. Melting point=37°-38°.
후처리
- temperaturethe mixture is heated to 250° for 6 hours
- temperatureIt is then cooled
- distillationdistilled under reduced pressure
출처 및 근거
- ORD 기록
- ord-a46083d02c5a416d934728269f0c973d
- 출처 데이터셋
- uspto-grants-1979_10
- 특허 번호
- US04172143
반응 노트
불러오는 중…