Ammonia → HCID 20544454, 화합물
반응식
O.[O:2]=[C:3]1[CH:8]=[C:7]([CH2:9][OH:10])O[CH:5]=[C:4]1[O:11][CH2:12][C:13]([O:15]CC)=[O:14].[NH3:18]>>[O:2]=[C:3]1[CH:8]=[C:7]([CH2:9][OH:10])[NH:18][CH:5]=[C:4]1[O:11][CH2:12][C:13]([OH:15])=[O:14]참가 물질
3
반응 조건
- 온도
- 120 °C
실험 절차
A mixture of ethyl 2-(4-oxo-6-hydroxymethyl-4H-pyran-3-yloxy)acetate monohydrate (10 g) in conc. ammonia was heated at 120° C. for 10 hours in a sealed vessel and the reaction mixture was concentrated. To the residue was added water and the resultant solution was adjusted to pH 1 to 2 with 10% hydrochloric acid. The resultant precipitates were washed with water and dried to give crystals (6 g) of 2-(4-oxo-6-hydroxymethyl-1,4-dihydropyridin-3-yloxy)acetic acid.
후처리
- concentrationthe reaction mixture was concentrated
- additionTo the residue was added water
- customThe resultant precipitates
- washwere washed with water
- customdried
출처 및 근거
- ORD 기록
- ord-df5eb099dd8f4019aae607684896a95f
- 출처 데이터셋
- uspto-grants-1979_10
- 특허 번호
- US04172198
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