Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → Ethyl 4-(piperidin-1-yl)benzoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Piperidine | HCID 8082 | — |
| 반응물 | Benzoic acid, 4-fluoro-, ethyl ester | HCID 67976 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | Ethyl 4-(piperidin-1-yl)benzoate | HCID 13813852 | — |
반응 단계
Reaction of ethyl 4-fluorobenzoate with piperidine (3 equivalents) in acetonitrile was carried out at reflux for 4 days. Dilution of the cooled reaction mixture with several volumes of water provided a precipitate, which was filtered to provide ethyl 4-(piperidin-1-yl)benzoate. Reduction of the ester with lithium aluminum hydride (2 equivalents) in tetrahydrofuran gave the corresponding alcohol (Examples 71, 72).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06313100B1 |
| 출처 데이터셋 | uspto-grants-2001_11 |
| ORD ID | ord-c8b15264a4eb4c2e9a59dd9bdeae15d9 |
| 출처 메모 | uspto-grants-2001_11 |