Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
5-Amino-1-methyl-1H-pyrazole-4-carbonitrile → 4Methoxy-2-(morpholin-4-yl)-benzothiazole-7-carboxylic acid (4-cyano-2-methyl-2H-pyrazol-3-yl)amide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 5-Amino-1-methyl-1H-pyrazole-4-carbonitrile | HCID 219740 | — |
| 반응물 | 4-Methoxy-2-(morpholin-4-yl)benzothiazole-7-carboxylic acid | HCID 18356991 | — |
| 촉매 | Dimethylformamide | HCID 6228 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 4Methoxy-2-(morpholin-4-yl)-benzothiazole-7-carboxylic acid (4-cyano-2-methyl-2H-pyrazol-3-yl)amide | HCID 10222513 | 11.4% |
반응 단계
Starting with 4-methoxy-2-(morpholin-4-yl)benzothiazole-7-carboxylic acid (0.13 g) oxalyl chloride (0.10 ml), dichloromethane (10 ml) and dimethylformamide (1 drop), followed by 5-amino-1-methyl-1H-pyrazole-4-carbonitrile (0.11 g), sodium hexamethyldisilylamine (1.0M in tetrahydrofuran, 0.88 ml) and dichloromethane (10 ml). Purification by flash chromatography (eluent ethyl acetate) yielded the title compound as an off-white solid (0.02 g). TLC Rf 0.45 (ethyl acetate); Mpt 299-300° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06313116B1 |
| 출처 데이터셋 | uspto-grants-2001_11 |
| ORD ID | ord-14080d70c0864b4f8ef496b3854154db |
| 출처 메모 | uspto-grants-2001_11 |