Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Isobutylamine → Boc-Ile-NH-CH2-CH(CH3)2
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Isobutylamine | HCID 6558 | — |
| 반응물 | Dicyclohexylcarbodiimide | HCID 10868 | — |
| 반응물 | 1-Hydroxybenzotriazole | HCID 75771 | — |
| 반응물 | tert-Butoxycarbonyl-L-isoleucine | HCID 2724762 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | Boc-Ile-NH-CH2-CH(CH3)2 | HCID 131722955 | — |
반응 단계
In a DMF solution containing 2.0 g of Boc-Ile-OH, 0.82 ml of isobutylamine, 1.27 g of HOBt and 2.06 g of DCC were added under ice cooling and the resultant mixture was stirred for 14 hr. The reaction mixture, after filtration, was treated similarly to that in Example 50 (Process 2), except for the crystallization solvent (hexane) to give 1.44 g of the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06313094B1 |
| 출처 데이터셋 | uspto-grants-2001_11 |
| ORD ID | ord-f043d0260b1949569a14578a54763201 |
| 출처 메모 | uspto-grants-2001_11 |