Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Hydroxide → 4-[3-(4-Carbamoylphenoxy)-1-pyrrolidinyl]pyridine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Hydroxide | HCID 14797 | — |
| 반응물 | 4-[3-(4-Cyanophenoxy)-1-pyrrolidinyl]pyridine | HCID 18357087 | — |
| 용매 | tert-Butanol | HCID 6386 | — |
| 생성물 | 4-[3-(4-Carbamoylphenoxy)-1-pyrrolidinyl]pyridine | HCID 18357100 | 57.8% |
반응 단계
A mixture of 4-[3-(4-cyanophenoxy)-1-pyrrolidinyl]pyridine (269 mg) and powdered potassium hydroxide (568 mg) in t-butanol (10 ml), under an atmosphere of argon, was heated under reflux for 18 hours. The mixture was filtered hot. The filtercake was washed with water and ethanol to give 4-[3-(4-carbamoylphenoxy)-1-pyrrolidinyl]pyridine (166 mg) as a colourless solid, mp 298-300° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06313127B1 |
| 출처 데이터셋 | uspto-grants-2001_11 |
| ORD ID | ord-1c442b2f30054d8ab9cea61c32b9e4d3 |
| 출처 메모 | uspto-grants-2001_11 |