Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triphenylphosphine → 4-[3-(4-Cyanophenoxy)-1-pyrrolidinyl]pyridine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triphenylphosphine | HCID 11776 | — |
| 반응물 | 4-Cyanophenol | HCID 13019 | — |
| 반응물 | ethyl N-ethoxycarbonyliminocarbamate | HCID 220568 | — |
| 반응물 | 1-(Pyridin-4-yl)pyrrolidin-3-ol | HCID 21906198 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 4-[3-(4-Cyanophenoxy)-1-pyrrolidinyl]pyridine | HCID 18357087 | 31.1% |
반응 단계
A solution of diethyl azodicarboxylate (1.73 ml) in dried tetrahydrofuran (10 ml) was added dropwise to a stirred mixture of triphenylphosphine (3.15 g), 4-cyanophenol (1.31 g) and 4-(3-hydroxy-1-pyrrolidinyl)pyridine (1.64 g) in dried tetrahydrofuran (45 ml), under an atmosphere of argon, at 5-7° C. The resulting solution was stirred at ambient temperature for 16 hours. The solid, which had separated, was filtered off and washed with diethyl ether to give 4-[3-(4-cyanophenoxy)-1-pyrrolidinyl]pyridine (823 mg) as an off-white solid, mp 182-185° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06313127B1 |
| 출처 데이터셋 | uspto-grants-2001_11 |
| ORD ID | ord-1a4f082357614521941d6c72489f4643 |
| 출처 메모 | uspto-grants-2001_11 |