Methanol → Methyl 6-amino-5-nitropyridine-3-carboxylate

HRID 427497노트

반응식

HRID 427497 반응식
Cl[C:2]1[C:10]([N+:11]([O-:13])=[O:12])=[CH:9][C:5]([C:6](Cl)=[O:7])=[CH:4][N:3]=1.[OH-:14].[NH4+:15].[CH3:16]O>>[NH2:15][C:2]1[C:10]([N+:11]([O-:13])=[O:12])=[CH:9][C:5]([C:6]([O:14][CH3:16])=[O:7])=[CH:4][N:3]=1

참가 물질

4

반응물 3

HCID 887MethanolHCID 14923Ammonium HydroxideHCID 113680196-Chloro-5-nitronicotinoyl chloride

생성물 1

HCID 13768248Methyl 6-amino-5-nitropyridine-3-carboxylate수율 45.9%

실험 절차

6-Chloro-5-nitronicotinoyl chloride (22.0 g, 0.1 mol) was cooled to +5° C. Methanol was added dropwise during 30 min and the reaction mixture was stirred for 60 min. The temperature was not allowed to raise over +10° C. Ammonium hydroxide (25%, 400 ml) was added dropwise to the reaction mixture and the mixture was stirred at room temperature for 20 h. The product was filtered off, washed with water and dried to give 9.0 g (45.9%) of the title compound.

후처리

  1. temperatureto raise over +10° C
  2. stirringthe mixture was stirred at room temperature for 20 h
  3. filtrationThe product was filtered off
  4. washwashed with water
  5. customdried

출처 및 근거

ORD 기록
ord-b8961e0ca40d41a384984305b55b3e15
출처 데이터셋
uspto-grants-2001_11
특허 번호
US06313137B1

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