Methyl 6-amino-5-nitropyridine-3-carboxylate → Methyl 5,6-diaminopyridine-3-carboxylate

HRID 427498노트

반응식

HRID 427498 반응식
[NH2:1][C:2]1[C:11]([N+:12]([O-])=O)=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][N:3]=1.[H][H]>[Pd].CO>[NH2:12][C:11]1[C:2]([NH2:1])=[N:3][CH:4]=[C:5]([CH:10]=1)[C:6]([O:8][CH3:9])=[O:7]

참가 물질

5

반응물 2

HCID 13768248Methyl 6-amino-5-nitropyridine-3-carboxylateHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 9920476Methyl 5,6-diaminopyridine-3-carboxylate

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

Methyl 6-amino-5-nitronicotinate (9.0 g, 46 mmol) and a small amount of Pd/C cat. were added to methanol (200 ml) and the mixture was hydrogenated at room temperature and atmospheric pressure until the uptake of hydrogen ceased. Following filtration through celite, the methanol was evaporated under reduced pressure to give the title compound, 7.0 g (92%).

후처리

  1. customwas hydrogenated at room temperature
  2. filtrationfiltration through celite
  3. customthe methanol was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-02d92824d41e468fa86f2ba63b09f304
출처 데이터셋
uspto-grants-2001_11
특허 번호
US06313137B1

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