Ethyl 2-chloroacetoacetate → Ethyl 8-amino-6-(aminocarbonyl)-2-methylimidazo[1,2-a]pyridine-3-carboxylate

HRID 427506노트

반응식

HRID 427506 반응식
[NH2:1][C:2]1[C:3]([NH2:11])=[N:4][CH:5]=[C:6]([CH:10]=1)[C:7]([NH2:9])=[O:8].[CH2:12]([O:14][C:15](=[O:21])[CH:16](Cl)[C:17]([CH3:19])=O)[CH3:13]>C(O)C>[NH2:1][C:2]1[C:3]2[N:4]([C:16]([C:15]([O:14][CH2:12][CH3:13])=[O:21])=[C:17]([CH3:19])[N:11]=2)[CH:5]=[C:6]([C:7]([NH2:9])=[O:8])[CH:10]=1

참가 물질

4

반응물 2

HCID 11858Ethyl 2-chloroacetoacetateHCID 99421905,6-Diaminonicotinamide

생성물 1

HCID 18357447Ethyl 8-amino-6-(aminocarbonyl)-2-methylimidazo[1,2-a]pyridine-3-carboxylate수율 12%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

5,6-Diaminonicotinamide (2.0 g, 13.4 mmol), ethyl-2-chloroacetoacetate (2.38 g, 14.4 mmol) and ethanol (40 ml) were refluxed for 20 h. The precipitate was isolated by filtration and washed with ethanol and diethyl ether. The solids were suspended in water, basified with a sodium hydroxide solution and isolated by filtration. Washing the solids with water and diethyl ether gave 0.42 g (12%) of the desired product.

후처리

  1. customThe precipitate was isolated by filtration
  2. washwashed with ethanol and diethyl ether
  3. customisolated by filtration
  4. washWashing the solids with water and diethyl ether

출처 및 근거

ORD 기록
ord-2b22776d263345f19074e980817f6d80
출처 데이터셋
uspto-grants-2001_11
특허 번호
US06313137B1

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