Ethanol → Ethyl 2-(2-bromo-3-methylphenyl)acetate

HRID 427516노트

반응식

HRID 427516 반응식
[Br:1][C:2]1[C:7]([CH3:8])=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:9][C:10]([OH:12])=[O:11].S(=O)(=O)(O)O.[CH2:18](O)[CH3:19]>>[Br:1][C:2]1[C:7]([CH3:8])=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:9][C:10]([O:12][CH2:18][CH3:19])=[O:11]

참가 물질

4

반응물 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 183574462-(2-Bromo-3-methylphenyl)acetic acid

생성물 1

HCID 18357438Ethyl 2-(2-bromo-3-methylphenyl)acetate

실험 절차

2-(2-bromo-3-methylphenyl)acetic acid (7.9 g, 0.034 mol) and sulfuric acid (0.1 ml) were added to ethanol (25 ml) and the mixture was refluxed overnight. The solvent was evaporated and to the residue was added saturated sodium carbonate. The aqueous solution was extracted twice with diethyl ether, the organic extracts were combiened, washed twice with water, dried and evaporated under reduced pressure to give the desired product as an oil. (8.5 g,97.7%).

후처리

  1. temperaturethe mixture was refluxed overnight
  2. customThe solvent was evaporated and to the residue
  3. additionwas added saturated sodium carbonate
  4. extractionThe aqueous solution was extracted twice with diethyl ether
  5. washwashed twice with water
  6. customdried
  7. customevaporated under reduced pressure

출처 및 근거

ORD 기록
ord-45b7bd54eed74222a9c186bc1d203dcd
출처 데이터셋
uspto-grants-2001_11
특허 번호
US06313137B1

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