Allyl bromide → 2-Allyloxy-5-bromobenzoic acid

HRID 427744노트

반응식

HRID 427744 반응식
[Br:1][C:2]1[CH:9]=[C:6]([CH:7]=[O:8])[C:5]([OH:10])=[CH:4][CH:3]=1.C(=O)([O-])[O-:12].[K+].[K+].[CH2:17](Br)[CH:18]=[CH2:19]>CN(C=O)C>[CH2:17]([O:10][C:5]1[CH:4]=[CH:3][C:2]([Br:1])=[CH:9][C:6]=1[C:7]([OH:12])=[O:8])[CH:18]=[CH2:19]

참가 물질

5

반응물 3

HCID 7841Allyl bromideHCID 11430Potassium CarbonateHCID 728635-Bromosalicylaldehyde

생성물 1

HCID 87071652-Allyloxy-5-bromobenzoic acid수율 41%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A solution of 5-bromo-salicylaldehyde (20.1 g, 100 mM) in DMF (50 ml) was treated with potassium carbonate (20.7 g, 150 mM) and allyl bromide (12.7 g, 10.5 mM). The reaction was stirred at ambient temperature for 18 hours. The reaction was partitioned between ethyl acetate/water. The organic phase was washed with water four times, dried (MgSO4) and evaporated at reduced pressure to give 2-allyloxy-5-bromobenzoic acid as a pale yellow oil (10.0 g, 41 %).

후처리

  1. customThe reaction was partitioned between ethyl acetate/water
  2. washThe organic phase was washed with water four times
  3. dry with materialdried (MgSO4)
  4. customevaporated at reduced pressure

출처 및 근거

ORD 기록
ord-6a6fe4789a62481b87e7327836099939
출처 데이터셋
uspto-grants-2001_11
특허 번호
US06313148B1

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