Ethylamine → 6-(Ethylamino)pyridine-3-carboxylic acid

반응식

Cl[C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][N:3]=1.[CH2:11]([NH2:13])[CH3:12]>>[CH2:11]([NH:13][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][N:3]=1)[CH3:12]

참가 물질

반응물 2

HCID 6341Ethylamine

HCID 792226-Chloronicotinic acid

생성물 1

HCID 117449946-(Ethylamino)pyridine-3-carboxylic acid수율 84%

반응 조건

온도: 170 °C

실험 절차

6-Chloronicotinic acid (100 g, 0.63 mol) was treated with ethylamine (70% in water, 500 ml). The reaction was sealed in an autoclave and heated to 170° C. for 6 hours. The reaction mixture was evaporated, partially neutralised with concentrated HCl and the pH adjusted to 5 with glacial acetic acid. The solid product was filtered off and dried in vacuo for 18 hours to give 6-(ethylamino)nicotinic acid (87.8 g, 84%).

후처리

customThe reaction was sealed in an autoclave
customThe reaction mixture was evaporated
filtrationThe solid product was filtered off
customdried in vacuo for 18 hours

출처 및 근거

ORD 기록: ord-7fe7c95260d642129e724b2c4f9e797d
출처 데이터셋: uspto-grants-2001_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06313148B1

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