1H-Indole, 1-(1-methoxyethyl)- → [1-(1-methoxy-ethyl)-1H-indol-3-yl]-oxo-acetyl chloride

HRID 427769노트

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HRID 427769 반응식
[CH3:1][O:2][CH:3]([N:5]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH:7]=[CH:6]1)[CH3:4].[C:14](Cl)(=[O:18])[C:15]([Cl:17])=[O:16]>C(OCC)C>[CH3:1][O:2][CH:3]([N:5]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[C:7]([C:14](=[O:18])[C:15]([Cl:17])=[O:16])=[CH:6]1)[CH3:4]

참가 물질

4

반응물 2

HCID 315761H-Indole, 1-(1-methoxyethyl)-HCID 65578Oxalyl chloride

생성물 1

HCID 18357717[1-(1-methoxy-ethyl)-1H-indol-3-yl]-oxo-acetyl chloride수율 31.1%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

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온도
0 °C

실험 절차

To a solution of 1-(1-methoxyethyl)indole (4 gm, 23 mmol) (prepared as in step a) above) in anhydrous diethyl ether at 0° C. was added oxalyl chloride (4.2 mL, 48 mmol) over 5 minutes. The resulting slurry was stirred at 0° C. for 5 hours, and filtered to afford 1.9 gm of [1-(1-methoxy-ethyl)-1H-indol-3-yl]-oxo-acetyl chloride. (Yield 31%). The material was used without further purification.

후처리

  1. filtrationfiltered

출처 및 근거

ORD 기록
ord-f31082a238384d90be116bd0f57a0ad4
출처 데이터셋
uspto-grants-2001_11
특허 번호
US06313143B1

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