Nitrogen → 6-(2-Methyl-1,3-dioxolan-2-yl)-2-pyridinecarboxaldehyde

HRID 42783노트

반응식

HRID 42783 반응식
N#N.Br[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]2([CH3:15])[O:14][CH2:13][CH2:12][O:11]2)[N:5]=1.[Li]CCCC.CN([CH:24]=[O:25])C.C([O-])(O)=O.[Na+]>CCOCC.CCCCCC>[CH3:15][C:10]1([C:6]2[N:5]=[C:4]([CH:24]=[O:25])[CH:9]=[CH:8][CH:7]=2)[O:14][CH2:13][CH2:12][O:11]1

참가 물질

8

반응물 5

HCID 947NitrogenHCID 6228DimethylformamideHCID 516892Sodium BicarbonateHCID 121642822-Bromo-6-(2-methyl-1,3-dioxolan-2-yl)pyridineHCID 178418339Butyllithium

생성물 1

HCID 860859206-(2-Methyl-1,3-dioxolan-2-yl)-2-pyridinecarboxaldehyde

시약·촉매·용매 2

HCID 3283Diethyl Ether용매HCID 8058Hexane용매

실험 절차

In a flame dried round-bottomed flask equipped with a magnetic stir bar and under inert atmosphere (N2), to a solution of 2-bromo-6-(2-methyl-[1,3]dioxolan-2-yl)-pyridine (2.21 g, 9.05 mmol) in Et2O (60.0 mL) at −78° C. was added dropwise n-BuLi (3.70 mL of a 2.5M solution in hexane, 9.25 mmol). The reaction mixture was then stirred at −78° C. for 30 min before DMF (0.85 mL, 11.00 mmol) was added dropwise. The reaction mixture was allowed to warm to rt over 1 h. 5% aq. NaHCO3 was added and the mixture was extracted three times with Et2O. The combined org. extracts were dried over Na2SO4, filtered, and the solvent was removed under reduced pressure. Purification of the residue by FC (4:1 hept-EA to pure EA) gave the title compound as a pale yellow solid.

후처리

  1. additionwas added dropwise
  2. extractionthe mixture was extracted three times with Et2O
  3. dry with materialextracts were dried over Na2SO4
  4. filtrationfiltered
  5. customthe solvent was removed under reduced pressure
  6. customPurification of the residue by FC (4:1 hept-EA to pure EA)

출처 및 근거

ORD 기록
ord-b6f1e6b0ab7c4d21ab68bddd2add98ac
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08536209B2

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