Nitrogen → 4-Chloromethyl-thiazole-2-carbaldehyde

HRID 42794

반응식

HRID 42794 반응식
N#N.[Cl:3][CH2:4][C:5]1[N:6]=[C:7]([CH2:10][OH:11])[S:8][CH:9]=1>C(C#N)(C)=O.O=[Mn]=O>[Cl:3][CH2:4][C:5]1[N:6]=[C:7]([CH:10]=[O:11])[S:8][CH:9]=1

참가 물질

5

반응물 2

HCID 947NitrogenHCID 11073749[4-(Chloromethyl)-1,3-thiazol-2-yl]methanol

생성물 1

HCID 552985444-Chloromethyl-thiazole-2-carbaldehyde

시약·촉매·용매 2

HCID 14801Manganese dioxide촉매HCID 694302-Oxopropiononitrile용매

실험 절차

In a flame dried round-bottomed flask equipped with a magnetic stir bar and under inert atmosphere (N2), a solution of (4-chloromethyl-thiazol-2-yl)-methanol (1.60 g, 9.80 mmol) in AcCN (98.0 mL) was treated at rt with MnO2 (4.73 g, 49.01 mmol). The reaction mixture was stirred at rt overnight before being filtered through Celite and the solvent was removed under reduced pressure. Purification of the residue by FC (4:1 hept-EA) gave the title compound as a colorless oil. TLC:rf (4:1 hept-EA)=0.37. LC-MS-conditions 02: tR=0.77 min.

후처리

  1. filtrationbefore being filtered through Celite
  2. customthe solvent was removed under reduced pressure
  3. customPurification of the residue by FC (4:1 hept-EA)

출처 및 근거

ORD 기록
ord-7a7c569c4fa34f09b0e58e1a59c58918
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08536209B2

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