3-Nitrophenylacetic acid → N-[(3-nitrophenyl)acetyl]-alanine iso-butyl ester

반응식

[N+:1]([C:4]1[CH:5]=[C:6]([CH2:10][C:11]([OH:13])=O)[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2].Cl.[CH2:15]([O:19][C:20](=[O:24])[C@H:21]([CH3:23])[NH2:22])[CH:16]([CH3:18])[CH3:17]>>[CH2:15]([O:19][C:20](=[O:24])[C@H:21]([CH3:23])[NH:22][C:11](=[O:13])[CH2:10][C:6]1[CH:7]=[CH:8][CH:9]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=1)[CH:16]([CH3:18])[CH3:17]

참가 물질

반응물 2

HCID 158763-Nitrophenylacetic acid

HCID 865849812-Methylpropyl (2S)-2-aminopropanoate hydrochloride

생성물 1

HCID 54157293N-[(3-nitrophenyl)acetyl]-alanine iso-butyl ester

실험 절차

Following General Procedure H above and using 3-nitrophenylacetic acid (Aldrich) and L-alanine iso-butyl ester hydrochloride (from Example B above), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by recrystallization from butyl chloride.

후처리

customThe reaction was monitored by tlc on silica gel and purification
customwas by recrystallization from butyl chloride

출처 및 근거

ORD 기록: ord-7a088584377c4796befe3c1c7b271828
출처 데이터셋: uspto-grants-2001_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06313152B1

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