methyl [3-[2-[(E)-3-(3-pyridyl)acryloylamino]ethyl]phenoxy]acetate → (E)-N-[3-[(methyl-carbamoyl) methoxy]phenethyl]-3-(3-pyridyl)-2-propenoic acid amide

HRID 428136노트

반응식

HRID 428136 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3](/[CH:7]=[CH:8]/[C:9]([NH:11][CH2:12][CH2:13][C:14]2[CH:15]=[C:16]([CH:23]=[CH:24][CH:25]=2)[O:17][CH2:18][C:19]([O:21]C)=O)=[O:10])[CH:2]=1.[CH3:26][NH2:27].CO>CO>[CH3:26][NH:27][C:19]([CH2:18][O:17][C:16]1[CH:15]=[C:14]([CH:25]=[CH:24][CH:23]=1)[CH2:13][CH2:12][NH:11][C:9](=[O:10])/[CH:8]=[CH:7]/[C:3]1[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=1)=[O:21]

참가 물질

4

반응물 2

HCID 20701346methyl [3-[2-[(E)-3-(3-pyridyl)acryloylamino]ethyl]phenoxy]acetateHCID 57454252Monomethylamine methanol

생성물 1

HCID 20701410(E)-N-[3-[(methyl-carbamoyl) methoxy]phenethyl]-3-(3-pyridyl)-2-propenoic acid amide수율 88%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Methyl [3-[2-[(E)-3-(3-pyridyl)acryloylamino]-ethyl]phenoxy]acetate (0.34 g, 1.0 mmol) obtained in Example 94 was dissolved in methanol (6 ml) and 40% methylamine-methanol solution (0.8 ml) was added and stirred at room temperature for 17 hours. After concentrating the reaction mixture under reduced pressure, the residue was recrystallized to yield the titled compound (0.30 g, 88%).

후처리

  1. concentrationAfter concentrating the reaction mixture under reduced pressure
  2. customthe residue was recrystallized

출처 및 근거

ORD 기록
ord-79678c02d7cc454e9768d133289dce14
출처 데이터셋
uspto-grants-2001_11
특허 번호
US06313153B1

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