Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Nitrogen → 1-[5-(tert-Butyl-dimethyl-silanyloxymethyl)-isoxazol-3-yl]-ethanone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Nitrogen | HCID 947 | — |
| 반응물 | 1-[5-(tert-Butyl-dimethyl-silanyloxymethyl)-isoxazol-3-yl]-ethanol | HCID 131730847 | — |
| 촉매 | Manganese dioxide | HCID 14801 | — |
| 용매 | 2-Oxopropiononitrile | HCID 69430 | — |
| 생성물 | 1-[5-(tert-Butyl-dimethyl-silanyloxymethyl)-isoxazol-3-yl]-ethanone | HCID 131730848 | — |
반응 단계
In a flame dried round-bottomed flask equipped with a magnetic stir bar and under inert atmosphere (N2), a solution of 1-[5-(tert-butyl-dimethyl-silanyloxymethyl)-isoxazol-3-yl]-ethanol (1.79 g, 6.95 mmol) in AcCN (70.0 mL) was treated at rt with MnO2 (3.36 g, 34.77 mmol) and the reaction mixture was stirred for 72 h at rt before being filtered through Celite. The solvent was removed under reduced pressure to give the title compound as a yellow oil. LC-MS-conditions 2: tR=1.13 min.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08536209B2 |
| 출처 데이터셋 | uspto-grants-2013_09 |
| ORD ID | ord-2bd598f7296c42d0b6c9205106043659 |
| 출처 메모 | uspto-grants-2013_09 |