Nitrogen → 1-[5-(tert-Butyl-dimethyl-silanyloxymethyl)-isoxazol-3-yl]-ethanone

HRID 42816

반응식

HRID 42816 반응식
N#N.[C:3]([SiH2:7][O:8][C:9]([CH3:19])([CH3:18])[C:10]1[O:14][N:13]=[C:12]([CH:15]([OH:17])[CH3:16])[CH:11]=1)([CH3:6])([CH3:5])[CH3:4]>C(C#N)(C)=O.O=[Mn]=O>[C:3]([SiH2:7][O:8][C:9]([CH3:19])([CH3:18])[C:10]1[O:14][N:13]=[C:12]([C:15](=[O:17])[CH3:16])[CH:11]=1)([CH3:6])([CH3:4])[CH3:5]

참가 물질

5

반응물 2

HCID 947NitrogenHCID 1317308471-[5-(tert-Butyl-dimethyl-silanyloxymethyl)-isoxazol-3-yl]-ethanol

생성물 1

HCID 1317308481-[5-(tert-Butyl-dimethyl-silanyloxymethyl)-isoxazol-3-yl]-ethanone

시약·촉매·용매 2

HCID 14801Manganese dioxide촉매HCID 694302-Oxopropiononitrile용매

실험 절차

In a flame dried round-bottomed flask equipped with a magnetic stir bar and under inert atmosphere (N2), a solution of 1-[5-(tert-butyl-dimethyl-silanyloxymethyl)-isoxazol-3-yl]-ethanol (1.79 g, 6.95 mmol) in AcCN (70.0 mL) was treated at rt with MnO2 (3.36 g, 34.77 mmol) and the reaction mixture was stirred for 72 h at rt before being filtered through Celite. The solvent was removed under reduced pressure to give the title compound as a yellow oil. LC-MS-conditions 2: tR=1.13 min.

후처리

  1. filtrationbefore being filtered through Celite
  2. customThe solvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-2bd598f7296c42d0b6c9205106043659
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08536209B2

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