Trichloroacetic Acid → 2,2,2-Trichloro-1,1-di(2,3,4,5,6-pentafluorophenyl)-1-ethanol

HRID 428352

반응식

HRID 428352 반응식
[F:1][C:2]1[C:7]([C:8](=[O:20])[C:9]2[C:14]([F:15])=[C:13]([F:16])[C:12]([F:17])=[C:11]([F:18])[C:10]=2[F:19])=[C:6]([F:21])[C:5]([F:22])=[C:4]([F:23])[C:3]=1[F:24].[Cl:25][C:26]([Cl:31])([Cl:30])C(O)=O.FF.C([O-])(=O)C=C>CO.CN(C)P(N(C)C)(N(C)C)=O>[Cl:25][C:26]([Cl:31])([Cl:30])[C:8]([C:9]1[C:10]([F:19])=[C:11]([F:18])[C:12]([F:17])=[C:13]([F:16])[C:14]=1[F:15])([C:7]1[C:2]([F:1])=[C:3]([F:24])[C:4]([F:23])=[C:5]([F:22])[C:6]=1[F:21])[OH:20]

참가 물질

7

반응물 4

HCID 6421Trichloroacetic AcidHCID 24524FluorineHCID 25188AcrylateHCID 70068Decafluorobenzophenone

생성물 1

HCID 226252562,2,2-Trichloro-1,1-di(2,3,4,5,6-pentafluorophenyl)-1-ethanol

시약·촉매·용매 2

HCID 887Methanol용매2회HCID 12679Hexamethylphosphoramide용매

반응 조건

온도
0 °C

실험 절차

A mixture of 4.9 g of decafluorobenzophenone and 2.7 g of trichloroacetic acid was added to 15 mL of hexamethylphosphoramide. The stirred reaction mixture was maintained at about 0° C. for about 2 hours and then allowed to warm to room temperature and continue stirring at ambient temperature for the next 15 hours. The reaction mixture was characterized by GC and fluorine NMR to show a conversion of approximately 20% to the desired carbinol. This carbinol can be converted to the corresponding acrylate by methods previously described (cf. Example 24).

후처리

  1. customThe stirred reaction mixture
  2. temperatureto warm to room temperature

출처 및 근거

ORD 기록
ord-9797598e0f8945dcacc0fb81a52e30ac
출처 데이터셋
uspto-grants-2001_11
특허 번호
US06313245B1

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