2-Vinylnaphthalene → HCID 15527073, 화합물

HRID 428368

반응식

HRID 428368 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[CH:14]([C:16]1[CH:25]=[CH:24][C:23]2[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=2)[CH:17]=1)=[CH2:15].[Li]CCCC>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[CH2:13][CH2:12][N:11]([CH2:15][CH2:14][C:16]3[CH:25]=[CH:24][C:23]4[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=4)[CH:17]=3)[CH2:10][CH2:9]2)=[CH:6][CH:7]=1

참가 물질

4

반응물 3

HCID 132302-VinylnaphthaleneHCID 752601-(4-Fluorophenyl)piperazineHCID 178418339Butyllithium

생성물 1

HCID 15527073HCID 15527073, 화합물

실험 절차

According to GP, 2.22 mmol (=0.40 g) of 1-(4-fluorophenyl)piperazine and 2.22 mmol (=0.34 g) of 2-vinylnaphthalene are reacted with 5 mol % (=0.111 mmol=70 μl) of n-BuLi solution. Column-chromatographic separation with ethyl acetate/n-hexane (1:1) gives the product 1-(4-fluorophenyl)-4-[2-(2-naphthyl)-1-ethyl]piperazine as a light-yellow solid.

후처리

  1. customColumn-chromatographic separation with ethyl acetate/n-hexane (1:1)

출처 및 근거

ORD 기록
ord-fd5fb53121034ed39783491c1f364175
출처 데이터셋
uspto-grants-2001_11
특허 번호
US06313297B1

연결된 노트

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