5-Bromoindole → 5-Bromo-3-(1,4-dioxaspiro[4.5]dec-7-en-8-yl)-1H-indole

HRID 428485노트

반응식

HRID 428485 반응식
[O:1]1[C:5]2([CH2:10][CH2:9][C:8]([C:11]3[C:19]4[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=4)[NH:13][CH:12]=3)=[CH:7][CH2:6]2)[O:4][CH2:3][CH2:2]1.[Br:20]C1C=C2C(=CC=1)NC=C2>>[O:4]1[C:5]2([CH2:10][CH2:9][C:8]([C:11]3[C:19]4[C:14](=[CH:15][CH:16]=[C:17]([Br:20])[CH:18]=4)[NH:13][CH:12]=3)=[CH:7][CH2:6]2)[O:1][CH2:2][CH2:3]1

참가 물질

3

반응물 2

HCID 249055-BromoindoleHCID 27638573-(1,4-Dioxaspiro[4.5]dec-7-en-8-yl)-1H-indole

생성물 1

HCID 27639895-Bromo-3-(1,4-dioxaspiro[4.5]dec-7-en-8-yl)-1H-indole수율 78%

실험 절차

This compound was prepared in the manner described above for intermediate 1a by replacing indole with 5-bromoindole (7.84 g, 40 mmol) ) to afford 10.5 g (78%) of the title compound as a white solid; MS EI m/e 333 (M+).

후처리

  1. customThis compound was prepared in the manner

출처 및 근거

ORD 기록
ord-3ee30fe089e346e7b74c0d501545e657
출처 데이터셋
uspto-grants-2001_11
특허 번호
US06313126B1

반응 노트

불러오는 중…