3-(1,4-Dioxa-spiro[4,5]dec-8-yl)-5-methoxy-1H-indole → 4-(5-Methoxy-1H-indol-3-YL)cyclohexanone

반응식

N1C2C(=CC=CC=2)C(C2CCC(=O)CC2)=C1.O1[C:21]2([CH2:26][CH2:25][CH:24]([C:27]3[C:35]4[C:30](=[CH:31][CH:32]=[C:33]([O:36][CH3:37])[CH:34]=4)[NH:29][CH:28]=3)[CH2:23][CH2:22]2)[O:20]CC1>>[CH3:37][O:36][C:33]1[CH:34]=[C:35]2[C:30](=[CH:31][CH:32]=1)[NH:29][CH:28]=[C:27]2[CH:24]1[CH2:25][CH2:26][C:21](=[O:20])[CH2:22][CH2:23]1

참가 물질

반응물 2

HCID 105893723-(1,4-Dioxa-spiro[4,5]dec-8-yl)-5-methoxy-1H-indole

HCID 108462644-(1H-Indol-3-YL)cyclohexanone

생성물 1

HCID 105382004-(5-Methoxy-1H-indol-3-YL)cyclohexanone수율 85%

실험 절차

This compound was prepared in the manner described above for intermediate 3a by replacing 3-(1,4-dioxa-spiro[4,5]dec-8-yl)-1H-indole with 3-(1,4-dioxa-spiro[4,5]dec-8-yl)-5-methoxy-1H-indole (5.85 g) to afford 4.2 g (85%) of the title compound as a white solid: mp 103-106° C.

후처리

customThis compound was prepared in the manner

출처 및 근거

ORD 기록: ord-1e386b0c7ffe4d38bd2b12eb9454e0c3
출처 데이터셋: uspto-grants-2001_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06313126B1

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