8-Amino-6-methoxy-3-methylquinoline → HCID 18414117, 화합물

HRID 428532노트

반응식

HRID 428532 반응식
[CH2:1]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:15]=[C:16]([O:25][CH3:26])[CH:17]=[C:18]3[C:23]=2[N:22]=[C:21](C)[CH:20]=[CH:19]3)[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.N[C:28]1C=C(OC)C=C2C=1N=CC(C)=C2.NC1C=C(OC)C=C2C=1N=C(C)C=C2>>[CH2:1]([N:8]1[CH2:9][CH2:10][N:11]([C:14]2[CH:15]=[C:16]([O:25][CH3:26])[CH:17]=[C:18]3[C:23]=2[N:22]=[CH:21][C:20]([CH3:28])=[CH:19]3)[CH2:12][CH2:13]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

4

반응물 3

HCID 6047528-Amino-6-methoxy-3-methylquinolineHCID 124995536-Methoxy-2-methyl-8-quinolinamineHCID 18414093HCID 18414093, 화합물

생성물 1

HCID 18414117HCID 18414117, 화합물수율 22%

실험 절차

The title compound was prepared by the same method used for 1-benzyl-4-(6-methoxy-2-methylquinolin-8-yl)piperazine, except substituting 8-amino-6-methoxy-3-methylquinoline (2.82 g, 15.0 mmol) for the 8-amino-6-methoxy-2-methyl-quinoline. Flash chromatography on 6×20 cm SiO2 (25-30% EtOAc/hexane), with rechromatography of the mixed fractions, provided 1.13 g (22%) of the title compound as a yellow gum. Crystallization from hexane afforded 0.88 g of analytically pure compound as yellow crystals: mp 112-113° C.

후처리

  1. customThe title compound was prepared by the same method

출처 및 근거

ORD 기록
ord-7db9dfd0fcf64a7e999e18a5dcb03eb8
출처 데이터셋
uspto-grants-2001_11
특허 번호
US06313126B1

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