HCID 18414093, 화합물 → 4-(6-Methoxy-3-methylquinolin-8-yl)piperazine
반응식
COC1C=C2C(=C(N3CCNCC3)C=1)N=C(C)C=C2.C([N:27]1[CH2:32][CH2:31][N:30]([C:33]2[CH:34]=[C:35]([O:44][CH3:45])[CH:36]=[C:37]3[C:42]=2[N:41]=[CH:40][C:39]([CH3:43])=[CH:38]3)[CH2:29][CH2:28]1)C1C=CC=CC=1.C(N1CCN(C2C=C(OC)C=C3C=2N=C(C)C=C3)CC1)C1C=CC=CC=1>>[CH3:45][O:44][C:35]1[CH:36]=[C:37]2[C:42](=[C:33]([N:30]3[CH2:31][CH2:32][NH:27][CH2:28][CH2:29]3)[CH:34]=1)[N:41]=[CH:40][C:39]([CH3:43])=[CH:38]2참가 물질
4
실험 절차
The title compound was prepared by the same method used for the preparation of 4-(6-methoxy-2-methylquinolin-8-yl)piperazine, except 1-benzyl-4-(6-methoxy-3-methylquinolin-8-yl)piperazine (0.32 g, 0.92 mmol) was substituted for the 1-benzyl-4-(6-methoxy-2-methylquinolin-8-yl)piperazine. The title compound was isolated in nearly quantitative yield and used with purification in the subsequent reaction.