3-(3-Benzyl-3H-imidazol-4-yl)-5-methoxy-6,7-dimethylindan-1-one → HCID 178486575, 화합물

HRID 428617노트

반응식

HRID 428617 반응식
C([N:8]1[C:12]([CH:13]2[C:21]3[C:16](=[C:17]([CH3:25])[C:18]([CH3:24])=[C:19]([O:22][CH3:23])[CH:20]=3)[C:15](=[O:26])[CH2:14]2)=[CH:11][N:10]=[CH:9]1)C1C=CC=CC=1>C(O)C.[Pd]>[NH:10]1[CH:11]=[C:12]([CH:13]2[C:21]3[C:16](=[C:17]([CH3:25])[C:18]([CH3:24])=[C:19]([O:22][CH3:23])[CH:20]=3)[C:15](=[O:26])[CH2:14]2)[N:8]=[CH:9]1

참가 물질

4

반응물 1

HCID 184052653-(3-Benzyl-3H-imidazol-4-yl)-5-methoxy-6,7-dimethylindan-1-one

생성물 1

HCID 178486575HCID 178486575, 화합물

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

3-(3-Benzyl-3H-imidazol-4-yl)-5-methoxy-6,7-dimethylindan-1-one (1.1 g) is dissolved in ethanol (90 ml). The reaction solution is hydrogenated at 50-55° C. with 10% palladium on carbon as catalyst for 7 hours. The mixture is filtered to remove the catalyst, and the filtrate is evaporated under reduced pressure. The product is converted to its hydrochloride salt in ethyl acetate using dry hydrochloric acid. The yield is 0.6 g, m.p. 258-261° C.

후처리

  1. filtrationThe mixture is filtered
  2. customto remove the catalyst
  3. customthe filtrate is evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-ee120878f08745b19a7414a1108d4a3f
출처 데이터셋
uspto-grants-2001_11
특허 번호
US06313311B1

반응 노트

불러오는 중…