2,4,5-Trimethoxybenzaldehyde → 3-Hydroxy-3-(2,4,5-trimethoxyphenyl)-1-propyne

HRID 428689노트

반응식

HRID 428689 반응식
[CH3:1][O:2][C:3]1[CH:10]=[C:9]([O:11][CH3:12])[C:8]([O:13][CH3:14])=[CH:7][C:4]=1[CH:5]=[O:6].[C:15]([Mg]Cl)#[CH:16]>C1COCC1>[OH:6][CH:5]([C:4]1[CH:7]=[C:8]([O:13][CH3:14])[C:9]([O:11][CH3:12])=[CH:10][C:3]=1[O:2][CH3:1])[C:15]#[CH:16]

참가 물질

4

반응물 2

HCID 205252,4,5-TrimethoxybenzaldehydeHCID 178462451HCID 178462451, 화합물

생성물 1

HCID 183592263-Hydroxy-3-(2,4,5-trimethoxyphenyl)-1-propyne

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

3-Hydroxy-3-(2,4,5-trimethoxyphenyl)-1-propyne was prepared according to Method A above from 2,4,5-trimethoxybenzaldehyde (0.784 g, 4 mmol) (Aldrich) in THF (20 mL) and ethynylmagnesium chloride (5 mmol, 10 mL, 0.5M solution in tetrahydrofuran) (Aldrich). (Yield 548 mg, 71%).

출처 및 근거

ORD 기록
ord-8abde0dc567c4c4f8bd01565a73b75e0
출처 데이터셋
uspto-grants-2001_11
특허 번호
US06313310B1

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