Water → HCID 178433222, 화합물

HRID 428732

반응식

HRID 428732 반응식
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[CH2:5]2.[CH3:12][C:13]1[N:14]=[CH:15][NH:16][C:17]=1[CH:18]=O.O>N1CCCCC1.CC(O)C>[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])/[C:5]/2=[CH:18]\[C:17]1[NH:16][CH:15]=[N:14][C:13]=1[CH3:12]

참가 물질

6

반응물 3

HCID 962WaterHCID 6111935-Bromo-2-oxindole2회HCID 27958875-Methyl-1H-imidazole-4-carbaldehyde

생성물 1

HCID 178433222HCID 178433222, 화합물

시약·촉매·용매 2

HCID 3776Isopropanol용매HCID 8082Piperidine용매

반응 조건

온도
90 °C

실험 절차

A mixture of 5-bromo-1,3-dihydro-2H-indol-2-one (0.3 g, 1.41 mmol) (Starting Material 6), and excess 4-methyl-5-imidazolecarboxaldehyde (0.25 g, 2.27 mmol) (Aldrich) in 1% piperidine in 2-propanol (6 mL) was heated at 90° C. for 4 h. Hot water (6 mL) was added. On cooling, the crystallized product was filtered off, washed with aqueous 2-propanol and dried. (Yield 0.44 g, 100%)

후처리

  1. temperatureOn cooling
  2. filtrationthe crystallized product was filtered off
  3. washwashed with aqueous 2-propanol
  4. customdried

출처 및 근거

ORD 기록
ord-aaf9cbd07db3496c87e20762bddfd593
출처 데이터셋
uspto-grants-2001_11
특허 번호
US06313310B1

연결된 노트

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