2-Chloro-4-fluorocinnamic acid → (E)-N-[2-(5-Acetyl-furan-2-ylmethyl)-2H-[1,2,3]triazol-4-yl]-3-(2-chloro-4-fluoro-phenyl)-acrylamide

HRID 42889

반응식

HRID 42889 반응식
[CH3:1][C:2]1([C:7]2[O:11][C:10]([CH2:12][N:13]3[N:17]=[C:16]([NH2:18])[CH:15]=[N:14]3)=[CH:9][CH:8]=2)[O:6]CCO1.[Cl:19][C:20]1[CH:25]=[C:24]([F:26])[CH:23]=[CH:22][C:21]=1/[CH:27]=[CH:28]/[C:29](O)=[O:30]>>[C:2]([C:7]1[O:11][C:10]([CH2:12][N:13]2[N:17]=[C:16]([NH:18][C:29](=[O:30])/[CH:28]=[CH:27]/[C:21]3[CH:22]=[CH:23][C:24]([F:26])=[CH:25][C:20]=3[Cl:19])[CH:15]=[N:14]2)=[CH:9][CH:8]=1)(=[O:6])[CH3:1]

참가 물질

3

반응물 2

HCID 62572972-Chloro-4-fluorocinnamic acidHCID 673642472-[5-(2-Methyl-[1,3]dioxolan-2-yl)-furan-2-ylmethyl]-2H-[1,2,3]triazol-4-ylamine

생성물 1

HCID 42645327(E)-N-[2-(5-Acetyl-furan-2-ylmethyl)-2H-[1,2,3]triazol-4-yl]-3-(2-chloro-4-fluoro-phenyl)-acrylamide

실험 절차

Following general procedure A followed by L, starting from 2-[5-(2-methyl-[1,3]dioxolan-2-yl)-furan-2-ylmethyl]-2H-[1,2,3]triazol-4-ylamine and (E)-3-(2-chloro-4-fluoro-phenyl)-acrylic acid.

출처 및 근거

ORD 기록
ord-b6978b6bf08d4bd6a915b80e3c4e5689
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08536209B2

연결된 노트

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