Methanesulfonyl chloride → HCID 22141210, 화합물
반응식
[CH3:1][C:2]1([C:17]2[CH:18]=[C:19]([NH2:23])[CH:20]=[CH:21][CH:22]=2)[CH:7]2[CH:3]1[CH2:4][N:5]([CH2:8][CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[CH2:6]2.[CH3:24][S:25]([Cl:28])(=[O:27])=[O:26]>CC(C)=O>[ClH:28].[CH3:1][C:2]1([C:17]2[CH:18]=[C:19]([NH:23][S:25]([CH3:24])(=[O:27])=[O:26])[CH:20]=[CH:21][CH:22]=2)[CH:3]2[CH:7]1[CH2:6][N:5]([CH2:8][CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[CH2:4]2참가 물질
4
실험 절차
To a solution of 3-[6-methyl-3-(3-phenylpropyl)-3-azabicyclo[3.1.0]hex-6-yl]phenylarnine (Preparation 8, 1.00 g, 3.26 mmol) in acetone (5 ml) at 0° C. was added methanesulfonyl chloride (0.28 ml, 3.58 mrol) and the reaction mixture was stirred at room temperature overnight. The resulting precipitate was collected by filtration to afford the title compound as a white crystalline solid (1.19 g, 87%).