3-Acetylpyridine → 1-(3-Pyridinyl)-1-ethanone hydrazone
반응식
[C:1]([C:4]1[CH:5]=[N:6][CH:7]=[CH:8][CH:9]=1)(=O)[CH3:2].O.O.[NH2:12][NH2:13]>O>[N:6]1[CH:7]=[CH:8][CH:9]=[C:4]([C:1](=[N:12][NH2:13])[CH3:2])[CH:5]=1참가 물질
4
실험 절차
To 3-acetylpyridine (6.1 g, 52 mmol) in industrial methylated spirits (50 ml) was added dropwise hydrazine hydrate monohydrate (3.11 ml, 0.1 mol). The reaction mixture was refluxed for 4 h, before cooling to room temperature and stirring for 16 h. Water (25 ml) was added and the volatile organics were removed in vacuo. The predominantly aqueous residual liquor was extracted with ethyl acetate, and the combined organic extracts were dried (Na2SO4) and concentrated to give a yellow oil (5.4 g, 80%) which was taken forward without further purification.
후처리
- temperatureThe reaction mixture was refluxed for 4 h
- customthe volatile organics were removed in vacuo
- extractionThe predominantly aqueous residual liquor was extracted with ethyl acetate
- dry with materialthe combined organic extracts were dried (Na2SO4)
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-038c360d8d524b7cae77a7c6c57cefe8
- 출처 데이터셋
- uspto-grants-2001_11
- 특허 번호
- US06313312B1
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