Sodium Iodide → 1-Benzyloxy-2-iodoethane
반응식
BrC1C=CC(S(O[CH2:12][CH2:13][O:14][CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)(=O)=O)=CC=1.[I-:22].[Na+]>CC(C)=O>[I:22][CH2:12][CH2:13][O:14][CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1참가 물질
4
실험 절차
To a solution of (benzyloxy)ethyl 4-bromobenzenesulfonate (Preparation 89, 6.92 g, 19.5 mmol) in acetone (60 ml) was added sodium iodide (5.84 g, 39.0 mmol) and the reaction mixture was left to stir at room temperature for 16 h. The resulting precipitate was filtered and the filtrate was concentrated in vacuo. The crude residue was dissolved in dichloromethane and washed with aqueous sodium thiosulphate solution and then with water (2×60 ml). The organic layer was dried (Na2SO4) and concentrated in vacuo to give the title compound as a pale brown oil (4.5 g, 88%).
후처리
- waitthe reaction mixture was left
- filtrationThe resulting precipitate was filtered
- concentrationthe filtrate was concentrated in vacuo
- dissolutionThe crude residue was dissolved in dichloromethane
- washwashed with aqueous sodium thiosulphate solution
- dry with materialThe organic layer was dried (Na2SO4)
- concentrationconcentrated in vacuo
출처 및 근거
- ORD 기록
- ord-4e03dfb26ace47de9bf4efe08ebfb3c6
- 출처 데이터셋
- uspto-grants-2001_11
- 특허 번호
- US06313312B1
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