Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 429생성일: 2026년 10월 23일
1-(Benzyloxy)-3-bromobenzene → 2-Methyl-1-(3-phenylmethoxyphenyl)-6-(trifluoromethoxy)indole
https://huagongshe.com/ko/reaction/429
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 1-(Benzyloxy)-3-bromobenzene | HCID 2756638 | — |
| 반응물 | 2-Methyl-6-(trifluoromethoxy)-1H-indole | HCID 12180669 | — |
| 시약 | Sodium t-butoxide | HCID 23676156 | — |
| 촉매 | 2-(Di-tert-butylphosphino)biphenyl | HCID 2734215 | — |
| 촉매 | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 2-Methyl-1-(3-phenylmethoxyphenyl)-6-(trifluoromethoxy)indole | HCID 59216720 | 59.07% |
반응 단계
EN04773-53, _Buchwald coupling, toluene and bromide_ The indole from 4773-25, 1-(benzyloxy)-3-bromobenzene,Pd2(dba)3, JohnPhos and KOtBu were dissolved in toluene. The mixture was warmed at 100 °C for 2h. Ca 60% conversion according to LCMS (product at 2.31 min). This conversion rate seemed faster than for the corresponding aryliodide. Big bacth was performed in 4773-54.
출처 및 근거
| 출처 데이터셋 | 750 AstraZeneca ELN dataset |
|---|
| ORD ID | ord-0addbbece6dc4ca2acdd8d8c9131d423 |
|---|
| 출처 메모 | 750 AstraZeneca ELN dataset |
|---|
