Ammonia → 4-Methoxyphenylbenzo[d]oxazole-4-carboxamide

HRID 429164노트

반응식

HRID 429164 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[O:10][C:11]3[C:12](=[C:14]([C:18]([O:20]C)=O)[CH:15]=[CH:16][CH:17]=3)[N:13]=2)=[CH:5][CH:4]=1.[NH3:22]>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[O:10][C:11]3[C:12](=[C:14]([C:18]([NH2:22])=[O:20])[CH:15]=[CH:16][CH:17]=3)[N:13]=2)=[CH:5][CH:4]=1

참가 물질

3

반응물 2

HCID 222Ammonia2회HCID 14616764Methyl 2-(4-methoxyphenyl)benzoxazole-4-carboxylate

생성물 1

HCID 183546064-Methoxyphenylbenzo[d]oxazole-4-carboxamide

실험 절차

Methyl 2-(4-methoxyphenyl)benzoxazole-4-carboxylate was dissolved in liquid ammonia (30 ml) and sealed in an autoclave. The reaction mixture was left at 55° C., 20 bar for >20 hours. Once the reaction was complete the ammonia was removed and the resulting solid recrystallised from boiling ethyl acetate and petrol.

후처리

  1. customsealed in an autoclave
  2. waitThe reaction mixture was left at 55° C.
  3. wait20 bar for >20 hours
  4. customwas removed
  5. customthe resulting solid recrystallised

출처 및 근거

ORD 기록
ord-c7d6a33dc7ff4b5889dd41a8a1ce92ed
출처 데이터셋
uspto-grants-2001_11
특허 번호
US06316455B1

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