Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Imidazole → Ethyl 3-(tributylsilyloxy)picolinate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Imidazole | HCID 795 | — |
| 반응물 | Water | HCID 962 | — |
| 반응물 | Tributylchlorosilane | HCID 70448 | — |
| 반응물 | Ethyl 3-hydroxypicolinate | HCID 15080989 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | Ethyl 3-(tributylsilyloxy)picolinate | HCID 22987980 | 49.7% |
반응 단계
A mixture of ethyl 3-hydroxypicolinate (15 g, 900 mmol), tributylsilyl chloride (16.23 g, 110 mmol), imidazole (8.0 g, 120 mmol) in methylene chloride was stirred overnight under a nitrogen atmosphere. Water was added and the methylene chloride layer was separated and concentrated in vacuo. Purification on a silica gel column using ethyl acetate-hexane (1:4) as the eluant gave ethyl 3-(tributylsilyloxy)picolinate as a solid (20 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06316464B1 |
| 출처 데이터셋 | uspto-grants-2001_11 |
| ORD ID | ord-9fa13fd9f5084314bf9621baed61acfd |
| 출처 메모 | uspto-grants-2001_11 |