(2R,5R)-2,5-dimethylpyrrolidine hydrochloride → 4'-{3-[(2R,5R)-2,5-dimethylpyrrolidinyl]propoxy}-N-isopropyl[1,1'-biphenyl]-4-carboxamide
반응식
Cl[CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH:17]=[CH:16][C:15]([C:18]([NH:20][CH:21]([CH3:23])[CH3:22])=[O:19])=[CH:14][CH:13]=2)=[CH:8][CH:7]=1.Cl.[CH3:25][C@@H:26]1[CH2:30][CH2:29][C@@H:28]([CH3:31])[NH:27]1>>[CH3:25][C@@H:26]1[CH2:30][CH2:29][C@@H:28]([CH3:31])[N:27]1[CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH:17]=[CH:16][C:15]([C:18]([NH:20][CH:21]([CH3:23])[CH3:22])=[O:19])=[CH:14][CH:13]=2)=[CH:8][CH:7]=1참가 물질
3
실험 절차
The product from Example 1A and (2R,5R)-2,5-dimethylpyrrolidine hydrochloride were processed as described in Example 10F to provide the title compound.
출처 및 근거
- ORD 기록
- ord-55f3176336e84fa2b6511fa176fe6771
- 출처 데이터셋
- uspto-grants-2001_11