(R)-(+)-N-Methyl-1-phenylethylamine → N-methyl-N-[(1R)-1-phenylethyl]-N-(3-{[4'-(1-pyrrolidinylcarbonyl)[1,1'-biphenyl]-4-yl]oxy}propyl)amine

HRID 429241

반응식

HRID 429241 반응식
Cl[CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH:17]=[CH:16][C:15]([C:18]([N:20]3[CH2:24][CH2:23][CH2:22][CH2:21]3)=[O:19])=[CH:14][CH:13]=2)=[CH:8][CH:7]=1.[CH3:25][NH:26][C@@H:27]([C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1)[CH3:28]>>[CH3:25][N:26]([C@@H:27]([C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1)[CH3:28])[CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH:17]=[CH:16][C:15]([C:18]([N:20]3[CH2:24][CH2:23][CH2:22][CH2:21]3)=[O:19])=[CH:14][CH:13]=2)=[CH:8][CH:7]=1

참가 물질

3

반응물 2

HCID 2060888(R)-(+)-N-Methyl-1-phenylethylamineHCID 22994486[4'-(3-Chloropropoxy)[1,1'-biphenyl]-4-yl](pyrrolidin-1-yl)methanone

생성물 1

HCID 20703894N-methyl-N-[(1R)-1-phenylethyl]-N-(3-{[4'-(1-pyrrolidinylcarbonyl)[1,1'-biphenyl]-4-yl]oxy}propyl)amine

실험 절차

The product from Example 11A and N-methyl-N-[(1R)-1-phenylethyl]amine were processed as described in Example 10F to provide the title compound.

출처 및 근거

ORD 기록
ord-ee784466adc346289945d347bac8281a
출처 데이터셋
uspto-grants-2001_11
특허 번호
US06316475B1

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