3-Hydroxypiperidine, (R)- → (3R)-1-(3-{[4'-(1-pyrrolidinylcarbonyl)[1,1'-biphenyl]-4-yl]oxy}propyl)-3-piperidinol

HRID 429243노트

반응식

HRID 429243 반응식
Cl[CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH:17]=[CH:16][C:15]([C:18]([N:20]3[CH2:24][CH2:23][CH2:22][CH2:21]3)=[O:19])=[CH:14][CH:13]=2)=[CH:8][CH:7]=1.[NH:25]1[CH2:30][CH2:29][CH2:28][C@@H:27]([OH:31])[CH2:26]1>>[N:20]1([C:18]([C:15]2[CH:16]=[CH:17][C:12]([C:9]3[CH:10]=[CH:11][C:6]([O:5][CH2:4][CH2:3][CH2:2][N:25]4[CH2:30][CH2:29][CH2:28][C@@H:27]([OH:31])[CH2:26]4)=[CH:7][CH:8]=3)=[CH:13][CH:14]=2)=[O:19])[CH2:24][CH2:23][CH2:22][CH2:21]1

참가 물질

3

반응물 2

HCID 27593343-Hydroxypiperidine, (R)-HCID 22994486[4'-(3-Chloropropoxy)[1,1'-biphenyl]-4-yl](pyrrolidin-1-yl)methanone

생성물 1

HCID 70141086(3R)-1-(3-{[4'-(1-pyrrolidinylcarbonyl)[1,1'-biphenyl]-4-yl]oxy}propyl)-3-piperidinol

실험 절차

The product from Example 11A and (3R)-3-piperidinol were processed as described in Example 10F to provide the title compound.

출처 및 근거

ORD 기록
ord-1952bd8667a845179e2d60779d5ff4f7
출처 데이터셋
uspto-grants-2001_11
특허 번호
US06316475B1

반응 노트

불러오는 중…