Thionyl Chloride → [3,4-bis(difluoromethoxy)phenyl]-(2-bromo-5-pyridyl) chloromethane

HRID 429244노트

반응식

HRID 429244 반응식
[F:1][CH:2]([F:23])[O:3][C:4]1[CH:5]=[C:6]([CH:14]([C:16]2[CH:17]=[N:18][C:19]([Br:22])=[CH:20][CH:21]=2)O)[CH:7]=[CH:8][C:9]=1[O:10][CH:11]([F:13])[F:12].O=S(Cl)[Cl:26].C([O-])(O)=O.[Na+]>C(Cl)Cl>[F:1][CH:2]([F:23])[O:3][C:4]1[CH:5]=[C:6]([CH:14]([C:16]2[CH:17]=[N:18][C:19]([Br:22])=[CH:20][CH:21]=2)[Cl:26])[CH:7]=[CH:8][C:9]=1[O:10][CH:11]([F:13])[F:12]

참가 물질

5

반응물 3

HCID 24386Thionyl ChlorideHCID 516892Sodium BicarbonateHCID 10971303HCID 10971303, 화합물

생성물 1

HCID 11144147[3,4-bis(difluoromethoxy)phenyl]-(2-bromo-5-pyridyl) chloromethane

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution [3,4-Bis(difluoromethoxy)phenyl]-(6-bromo-3-pyridyl)methanol (15.8 g, 40.0 mmol) in 400 mL of CH2Cl2, was added 3.8 mL (52.0 mmol) of SOCl2. The solution was stirred 45 minutes at room temperature and poured into a saturated aqueous solution of NaHCO3. The aqueous layer was extracted with CH2Cl2 and the combined organic layers were dry over MgSO4 and concentrated under reduced pressure. The crude chloride was used directly for the next step without any purification.

후처리

  1. extractionThe aqueous layer was extracted with CH2Cl2
  2. dry with materialthe combined organic layers were dry over MgSO4
  3. concentrationconcentrated under reduced pressure
  4. customThe crude chloride was used directly for the next step without any purification

출처 및 근거

ORD 기록
ord-04b9e7d4b0b94594afa2eb78d2a30d9f
출처 데이터셋
uspto-grants-2001_11
특허 번호
US06316472B1

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