참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Nitrogen | HCID 947 | — |
| 반응물 | 3-[4-(Methylthio)phenyl]acrylonitrile | HCID 4239680 | — |
| 반응물 | Sodium Methoxide | HCID 10942334 | — |
| 반응물 | (3-Cyano-4-methoxyphenyl)hydrazine hydrochloride | HCID 18355391 | — |
| 용매 | Methanol | HCID 887 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 1-(3-Cyano-4-methoxyphenyl)-5-[4-(methylthio)phenyl]-2-pyrazoline-3-amine | HCID 18355404 | 90.1% |
반응 단계
A stirred mixture of (3-cyano-4-methoxyphenyl)hydrazine hydrochloride (3.7 g), 3-[4-(methylthio)phenyl]acrylonitrile (2.3 g) and sodium methoxide (0.9 g) in methanol 13 ml was gradually heated to 140° C. under atmospheric pressure and N2 atmosphere, and continued to heat for 8 hours at 140° C. Ethyl acetate and water were added to the reaction mixture. The organic layer was separated, washed with brine, dried over magnesium sulfate, and concentrated under reduced pressure to give crude 1-(3-cyano-4-methoxyphenyl)-5-[4-(methylthio)-phenyl]-2-pyrazoline-3-amine (4.0 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06316485B1 |
|---|
| 출처 데이터셋 | uspto-grants-2001_11 |
|---|
| ORD ID | ord-7b4b74057c9f41a9ae4432725fa8f793 |
|---|
| 출처 메모 | uspto-grants-2001_11 |
|---|
