참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Ammonia | HCID 222 | — |
| 반응물 | Bromine | HCID 24408 | — |
| 반응물 | 1-methyl-1H-1,3-benzodiazol-5-amine | HCID 315499 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 생성물 | 1-Methyl-4-bromo-5-aminobenzimidazole | HCID 12968451 | 50% |
반응 단계
1-methyl-5-aminobenzimidazole (0.36 g, 2.4 mmol) in 10 ml of AcOH was added Br2 (0.12 ml). The reaction mixture was stirred for 1 h at 25° C. and concentrated in vacuo, yielding an oil which was subjected to column chromatography (NH3 sat'd 3% MeOH/CHCl3) to yield 0.27 g (1.2 mmol, 50%) of the desired product.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06316637B1 |
|---|
| 출처 데이터셋 | uspto-grants-2001_11 |
|---|
| ORD ID | ord-988bc22c2ab84888860fa2343a3f5991 |
|---|
| 출처 메모 | uspto-grants-2001_11 |
|---|
